AUTOIMMUNE INFLAMMATORY SYNDROME (ASIA)
Silicone has been widely used in the manufacture of medical implants. It is well tolerated in most cases. However, in this paper, we report the cases of three women who developed autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), namely with silicone breast implants. The symptoms in these cases include arthralgia, arthritis, myalgia, sleep disturbances, the appearance of autoantibodies, miscarriage, Raynaud’s phenomenon, and involvement of autoimmune diseases (scleroderma and undifferentiated connective tissue diseases).
In one patient, breast implants were removed, but no improvement was seen after the removal. The remaining two patients received updated information about their condition, and they decided not to remove the implants. In conclusion, earlier reports that silicone is biologically relatively inert have recently been challenged with the description of ASIA syndrome.
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Silicone-reactive disorder: A new autoimmune disease caused by immunostimulation and superantigens Over 100 cases of disorders closely resembling classic autoimmune diseases have been reported among patients who were injected or implanted with a diverse group of chemicals including paraffin, vegetable oils or silicone (1–30).
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Women with silicone breast implants and autoimmune inflammatory syndrome induced by adjuvants Silicone has been widely used in the manufacture of medical implants. It is well tolerated in most cases. However, in this paper, we report the cases of three women who developed autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), namely with silicone breast implants.
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